Knowledge Hub

DR. ANNIE™ was developed based on about 50,000 successfully treated cases selected from about 200,000 completed cases that has been collected, deidentified and cataloged from multiple clinicians using different treatment philosophies, mechanics and approaches over the past 30 years. Besides being trained to identify landmarks and other dental conditions from radiographs as well as Intraoral scans/photographs, a complex evidence-based and series of algorithm was used to develop the first AI model.

The decision tree AI models were then being perfected from those thousands of completed cases in which it learned the types of treatments, tooth movements, case complexity, length of treatment, growth prediction and beyond. Gradient Boost, XGBoost, Random Forest and many other AI models were used and validated to mature the decision of DR. ANNIE™ over time. Validation studies for the identification of structures (patented technology) as well as prediction of treatment length and degree of difficulties have been done and published as part of independent university study (2023, 2025).

It automates ceph tracing and analysis, treatment sequencing, and aligns plans with the doctor’s style. Rather than manually entering measurements or decisions, the AI delivers a fully structured case—including objectives, planning and treatment staging in approximately under 3 minutes.

Yes. While the system currently uses generalized models, it is designed to learn from each user’s treatment behavior. Over 6–12 months, the AI retrains on user-specific patterns to provide increasingly personalized outputs.

The HLD (Handicapping Labio-Lingual Discrepancy) Index is used to evaluate case difficulty automatically within approximately 90 seconds. If a case scores above a certain threshold (e.g., 20+ points), it is flagged as complex—indicating that an orthodontist should handle it. It serves as both a clinical guide and a filter.

No. The system supports clinical judgment by providing a second opinion, validating feasibility, and documenting rationale. Experienced orthodontists may not rely on tracings, but they still benefit from AI-DR.iven models as confirmation and efficiency tools.

The system is designed to facilitate collaboration. GPs can handle straightforward cases with AI assistance, while orthodontists supervise, approve, or fully take over complex cases. This helps maintain standards in a world where GPs increasingly practice ortho.

When AI cannot confidently process a case (due to anomalies like ectopic teeth, missing dentition, etc.), the VIP button sends the case to a human orthodontist for manual review and treatment planning. It ensures difficult cases still receive expert oversight.

The system rapidly analyzes intraoral findings, occlusogram (can be from digital 3D scan) and cephalometric data, generating a structured treatment rationale in just minutes. Such tools can help orthodontists and general dentists achieve more predictable results by integrating cephalometric analysis—often overlooked in daily practice—into a seamless workflow.

There are multiple report types—Standard, Standard Plus, Complete and VIP Premium. A standard plus report (with intraoral photos and lateral ceph) is generated in around 3 minutes more or less, with the first sections available within the first 90 seconds. For complex cases, the VIP Premium option includes a human orthodontist's review.

Pricing ranges from $5 to $15 per case (depending on the complexity of the reports requested) with more discounts for the upper tier.

The Narrative function of DR. ANNIE is a LLM (Large Language Model) - powered feature that converts data into a natural-language explanation of the diagnosis and treatment plan. It includes details about skeletal pattern, growth, staging, and cephalometric findings. This part may take approximately 8–10 minutes to complete because it synthesizes all variables into coherent clinical recommendations—like whether removal of certain teeth are recommended, or modify growth or smile lines.

This narrative particularly valuable for understanding and explaining complex cases in more lay-term language. The narrative also provides a step-by-step treatment staging in which can be directly copy-pasted as instruction to the aligners technician to facilitate their setup and aligner design.

The AI detects approximately 90-95% of points accurately. For legal and verification purposes, clinicians are still required to confirm the suggested landmarks. However, professionals can distinguish most cases can be quickly confirmed by just clicking through if no major anomalies are detected.

For difficult cases (e.g., multiple impacted or missing teeth, severe skeletal issues), DR. ANNIE™ includes a VIP review process. Clinicians can flag these cases, and a professional will manually review and clean up the analysis. This process can take 1-2 days depending on complexity.

Even experienced orthodontists may misjudge case difficulty. DR. ANNIE™ can serve as a second opinion, offering fast, data-backed assessments to improve treatment planning, adjust patient fees, and communicate expectations more clearly. This evidence-based support can streamline consultations and reduce inconsistencies.

The Narrative and sequencing steps can be directly copied and sent to aligner manufacturers. This ensures their first proposed setups are more realistic and require less manual adjustment. This reduces the back-and-forth in treatment planning and improves outcomes.

A clear in-office protocol is recommended. Staff can pre-check for warning signs in the HLD form (e.g., multiple impacted teeth, severe hygiene issues). If too many red flags appear, the case should be escalated to the VIP process. For most routine cases, staff can handle the verification process quickly using guided checklists.